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                      DNA-PKcs (DNA-dependent protein kinase, catalytic subunit) is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. DNA-PKcs is the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct it to DNA ends and trigger its kinase activity. DNA-PKcs is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Many proteins have been identified as substrates for the kinase activity of DNA-PK. Autophosphorylation of DNA-PKcs appears to play a key role in NHEJ and is thought to induce a conformational change that allows end processing enzymes to access the ends of the double-strand break. DNA-PK also cooperates with ATR and ATM to phosphorylate proteins involved in the DNA damage checkpoint.

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                      1300118-55-1

                      BD6300981300118-55-198+%

                      ¥602.001mg

                      1386874-06-1

                      BD6302091386874-06-198+%

                      ¥3916.0025mg

                      69304-47-8

                      BD11923969304-47-895%

                      ¥698.00100mg

                      503468-95-9

                      BD305840503468-95-998+%

                      ¥2490.0050mg

                      154447-35-5

                      BD316905154447-35-598+%

                      ¥754.0010mg

                      69541-04-4

                      BD44824369541-04-497%

                      ¥4657.0050mg

                      79105-88-7

                      BD33537579105-88-795+%

                      ¥13962.00250mg

                      1228013-15-7

                      BD6300241228013-15-798+%

                      ¥8184.00100mg

                      19545-26-7

                      BD15660919545-26-798+%

                      ¥299.001mg

                      371935-74-9

                      BD157912371935-74-998+%

                      ¥3221.0050mg

                      842122-14-9

                      BD335471842122-14-995+%

                      ¥4657.0050mg

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